CA · Irvine · Updated October 15, 2026

Ambulatory and clinic nurse jobs in Irvine, CA

Registered Nurses in the Irvine area earn a median of $64.16 per hour, about $133,440 a year, and the middle half of them earn between $51.99 and $79.47. That ranks 15th of 379 U.S. metro areas for registered nurse pay, and 27th of 335 once local prices are factored in. 2 open roles with published pay are listed for Irvine. Tell us your role and we email current openings near Irvine.

Open Ambulatory and clinic nurse roles in Irvine

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Registered Nurse pay in Irvine, CA

The metro median is 5% below the California statewide median of $67.47 per hour. Nationally the median is $45.00 per hour. BLS counts about 107,340 registered nurses employed in the Los Angeles-Long Beach-Anaheim metro area, 17.3 per 1,000 jobs. Employment is less concentrated here than in the country as a whole (location quotient 0.81).

LevelPer hourPer yearCompared with U.S.
Lowest 10%$47.85$99,5306% above U.S. median
Lower quartile$51.99$108,14016% above U.S. median
Median$64.16$133,44043% above U.S. median
Upper quartile$79.47$165,30077% above U.S. median
Top 10%$83.05$172,74085% above U.S. median

How Irvine ranks

  • 15th of 379 U.S. metro areas by median hourly pay
  • 27th of 335 after adjusting for local prices
  • 13th of 23 California metro areas

BLS does not publish a separate figure for ambulatory and clinic nurse. These numbers are for the broader category it belongs to, Registered Nurses.

Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics, May 2024, Registered Nurses (SOC 29-1141), all industries. This is what employers report paying, not an offer for a specific role.

What your pay buys in Irvine

  • Overall prices in Los Angeles-Long Beach-Anaheim run 14% above the U.S. average (index 113.6, U.S. = 100).
  • Housing is the biggest driver: 70% above the U.S. average (index 170.4).
  • Adjusted for local prices, a $64.16 median hour buys what $56.50 buys at the national price level, 26% above the national median.

Source: U.S. Bureau of Economic Analysis, Regional Price Parities by metropolitan area, 2024. Prices are for the metro area, not for a single neighborhood.

Estimate your Irvine paycheck

Estimated weekly gross$2,310
  • Per year: $115,488
  • Per month: $9,624

Gross pay before taxes and benefits, from BLS pay levels for the Los Angeles-Long Beach-Anaheim metro area. For take-home pay use the take-home pay calculator.

Travel assignment per diem in Irvine

ItemFederal rate
Lodging per night$191
Meals and incidentals per day$86
Per week (7 nights, 7 days)$1,939
13-week assignment$25,207

Travel ambulatory and clinic nurse assignments commonly pay housing and meals stipends. The GSA per diem is the federal benchmark for what those stipends can be tax-free. Whether a stipend is tax-free for you depends on keeping a valid tax home, so confirm with your recruiter and a tax professional. Compare with your offer in the travel pay calculator.

Source: U.S. General Services Administration per diem rates, fiscal year 2026 (average across months).

Hospitals in Irvine

CMS lists 1 hospital in Irvine. Hospitals are a major employer of ambulatory and clinic nurses.

HospitalTypeOwnershipCMS ratingEmergency
Hoag Orthopedic Institute
Irvine, CA
Acute careFor-profitNot ratedNo

Source: CMS Hospital General Information, public data. A directory of hospitals, not a list of our clients.

Primary care shortage areas in Orange County

HRSA lists 19 active primary care shortage designations that include Orange County (2 population-group, 17 facility). The highest-scoring one rates 19 on a 0 to 25 scale, where a higher score means a greater shortage.

Shortage areas are where demand for nurses, nurse practitioners, physician assistants and other clinicians is greatest. Federal loan repayment programs such as the NHSC and Nurse Corps cover some clinicians who work at eligible shortage-area sites. Eligibility is set by each program and by the site, so ask your recruiter before you plan around it.

Source: HRSA Health Professional Shortage Areas data warehouse, designated areas only. A designation can cover part of a county.

License and tax basics in California

California is not in the Nurse Licensure Compact as of October 15, 2026, so a nurse licensed elsewhere applies to the California board for a license by endorsement before working here.

California taxes wage income. Use your own rates in the take-home pay calculator.

California state guide · Nurse Licensure Compact guide

Other healthcare roles in Irvine

Irvine city guide: hospitals, employers and licensing

Common questions

How much do ambulatory and clinic nurses make in Irvine, CA?

BLS reports pay for registered nurses overall, not by specialty. Registered Nurses in the Los Angeles-Long Beach-Anaheim metro area have a median pay of $64.16 per hour, about $133,440 a year. The middle half earn between $51.99 and $79.47 per hour (BLS, May 2024).

Is Irvine a good place for ambulatory and clinic nurses once cost of living is counted?

Los Angeles-Long Beach-Anaheim ranks 27th of 335 metro areas for registered nurse pay after adjusting for local prices, and 15th of 379 before adjusting. Overall prices run 14% above the U.S. average.

Who is hiring ambulatory and clinic nurses in Irvine?

We list 2 open roles with published pay from 1 employer in Irvine. Your free report adds named employers and pay near Irvine.

Do I need a California license to work in Irvine as an ambulatory and clinic nurse?

California is not in the Nurse Licensure Compact as of October 15, 2026, so a nurse licensed elsewhere applies to the California board for a license by endorsement before working here. Confirm with the board before you accept a role.

Is Irvine in a shortage area?

HRSA lists 19 active primary care shortage designations that include Orange County. Shortage areas often have more openings, and some loan repayment programs cover clinicians who work at eligible sites.

What is the per diem for a travel assignment in Irvine?

The federal per diem benchmark in Irvine is $191 a night for lodging and $86 a day for meals and incidentals, about $1,939 a week (GSA, fiscal year 2026). Your actual stipend depends on the assignment and your tax home.

Does Valorem Health place ambulatory and clinic nurses in Irvine?

Yes. We place healthcare staff in Irvine and across California. Tell us your profession and we email the roles open near Irvine.

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The Joint Commission Gold Seal of Approval: Health Care Staffing Services Certification, since 2022American Staffing Association memberNATHO member: National Association of Travel Healthcare OrganizationsNALTO member: National Association of Locum Tenens Organizations

Pay report · RN near Irvine, CA
Valorem Health Shift ReportFrom your recruiting team · [email protected]

Your RN pay reportIrvine, CA · pay published by hospitals, collected October 15, 2026

1Pay for your role at other hospitals

  • Hoag Memorial Hospital PresbyterianIrvine, CA · 2 postings$63.71/ hr$48–$79
  • El Camino HealthMountain View, CA · 3 postings$108.25/ hr$94–$123
  • MarinHealthGreenbrae, CA · 16 postings$106.18/ hr$59–$119
  • Stanford Children's HealthPALO ALTO, CA · 8 postings$103.75/ hr$90–$113

Median posted pay per hour, with the range each employer published.

2What they are offering now

Low$50Median$66.48High$79

536 RN postings with published pay in California, 518 of them posted in the last 30 days. Month-by-month history by employer comes with your full report.

3Open now: 536 RN roles

  1. RN Float PoolPer diem
    $103.83–$112.14/ hour
    CommonSpirit Health · Santa Cruz, CA · posted today
  2. RN Physical RehabilitationPer diem
    $103.83–$112.14/ hour
    CommonSpirit Health · Santa Cruz, CA · posted today

+ 534 more in your report. Each one has pay, shift and start date.

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