MO · St. Louis · Updated October 15, 2026

Nurse Practitioner jobs in St. Louis, MO

Pay for nurse practitioners in the St. Louis area centers on $62.21 per hour, or about $129,390 a year. The lower quarter earns under $54.68 and the upper quarter over $72.11. That ranks 126th of 372 U.S. metro areas for nurse practitioner pay, and 139th of 336 once local prices are factored in. The CMS hospital directory lists 11 hospitals in St. Louis. Tell us your role and we email current openings near St. Louis.

More open Nurse Practitioner roles in St. Louis

1 more open role from employers in St. Louis. Each employer’s range arrives with your free pay report.

Nurse Practitioner pay in St. Louis, MO

The metro median is 2% above the Missouri statewide median of $60.75 per hour. Nationally the median is $62.12 per hour. BLS counts about 3,360 nurse practitioners employed in the St. Louis metro area, 2.5 per 1,000 jobs. Employment is more concentrated here than in the country as a whole (location quotient 1.26).

LevelPer hourPer yearCompared with U.S.
Lowest 10%$46.44$96,60025% below U.S. median
Lower quartile$54.68$113,73012% below U.S. median
Median$62.21$129,390in line with U.S. median
Upper quartile$72.11$149,99016% above U.S. median
Top 10%$73.02$151,88018% above U.S. median

How St. Louis ranks

  • 126th of 372 U.S. metro areas by median hourly pay
  • 139th of 336 after adjusting for local prices
  • 2nd of 8 Missouri metro areas

Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics, May 2024, Nurse Practitioners (SOC 29-1171), all industries. This is what employers report paying, not an offer for a specific role.

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Named employers near St. Louis, what they pay and the roles open now. Free for candidates, email only.

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What your pay buys in St. Louis

  • Overall prices in St. Louis run 5% below the U.S. average (index 95.1, U.S. = 100).
  • Housing is the biggest driver: 21% below the U.S. average (index 79.0).
  • Adjusted for local prices, a $62.21 median hour buys what $65.42 buys at the national price level, 5% above the national median.

Source: U.S. Bureau of Economic Analysis, Regional Price Parities by metropolitan area, 2024. Prices are for the metro area, not for a single neighborhood.

Estimate your St. Louis paycheck

Estimated weekly gross$2,240
  • Per year: $111,978
  • Per month: $9,332

Gross pay before taxes and benefits, from BLS pay levels for the St. Louis metro area. For take-home pay use the take-home pay calculator.

Travel assignment per diem in St. Louis

ItemFederal rate
Lodging per night$150
Meals and incidentals per day$86
Per week (7 nights, 7 days)$1,652
13-week assignment$21,476

Travel nurse practitioner assignments commonly pay housing and meals stipends. The GSA per diem is the federal benchmark for what those stipends can be tax-free. Whether a stipend is tax-free for you depends on keeping a valid tax home, so confirm with your recruiter and a tax professional. Compare with your offer in the travel pay calculator.

Source: U.S. General Services Administration per diem rates, fiscal year 2026 (average across months).

Open Nurse Practitioner roles in Missouri

Nearest open roles with published pay. Your free report adds roles in St. Louis as they open.

PermanentPosted 9 days ago

Advanced Practice Nurse

Veterans Health Administration · Kansas City, MO

$127k–$186k/ year
  • Full-time
  • Req 887787700
Top 25% pay
View role

All Nurse Practitioner jobs in Missouri

Hospitals in St. Louis

CMS lists 11 hospitals in St. Louis, 5 of the 8 rated ones with 4 or 5 stars. Hospitals are a major employer of nurse practitioners.

HospitalTypeOwnershipCMS ratingEmergency
Missouri Baptist Medical Center
Saint Louis, MO
Acute careNonprofit5 of 5Yes
St Louis-John Cochran Va Medical Center
St. Louis, MO
Acute Care - Veterans AdministrationGovernment and federal5 of 5Yes
Barnes Jewish Hospital
Saint Louis, MO
Acute careNonprofit4 of 5Yes
Christian Hospital Northeast
Saint Louis, MO
Acute careNonprofit4 of 5Yes
Mercy Hospital St Louis
Saint Louis, MO
Acute careNonprofit4 of 5Yes
Ssm Health St Mary's Hospital - St Louis
Saint Louis, MO
Acute careNonprofit3 of 5Yes
Mercy Hospital South
Saint Louis, MO
Acute careNonprofit2 of 5Yes
Ssm Health Saint Louis University Hospital
Saint Louis, MO
Acute careNonprofit1 of 5Yes
Shriners Hospitals For Children
Saint Louis, MO
Children'sNonprofitNot ratedNo
St Louis Childrens Hospital
Saint Louis, MO
Children'sNonprofitNot ratedYes

Source: CMS Hospital General Information, public data. A directory of hospitals, not a list of our clients.

Primary care shortage areas in St. Louis city

HRSA lists 5 active primary care shortage designations that include St. Louis city (2 population-group, 3 facility). The highest-scoring one rates 24 on a 0 to 25 scale, where a higher score means a greater shortage.

Shortage areas are where demand for nurses, nurse practitioners, physician assistants and other clinicians is greatest. Federal loan repayment programs such as the NHSC and Nurse Corps cover some clinicians who work at eligible shortage-area sites. Eligibility is set by each program and by the site, so ask your recruiter before you plan around it.

Source: HRSA Health Professional Shortage Areas data warehouse, designated areas only. A designation can cover part of a county.

Nurse Practitioner pay in nearby cities

CityDistanceMedian payPopulation
Florissant, MO12 mi$62.21/hr51,290
St. Charles, MO18 mi$62.21/hr72,458
Springfield, IL86 mi$60.34/hr112,949
Decatur, IL110 mi$56.23/hr68,763
Columbia, MO114 mi$52.82/hr130,900
Bloomington, IL144 mi$62.15/hr79,232

Nurse Practitioner jobs in Missouri · Nurse Practitioner jobs nationwide

License and tax basics in Missouri

Missouri is in the Nurse Licensure Compact, so an RN or LPN/LVN with a multistate license from another compact state can work here without a new license. Nurses whose home state is not in the compact apply for a Missouri license by endorsement.

Missouri taxes wage income. Use your own rates in the take-home pay calculator.

Missouri state guide · Nurse Licensure Compact guide

Other healthcare roles in St. Louis

St. Louis city guide: hospitals, employers and licensing

Common questions

How much do nurse practitioners make in St. Louis, MO?

Nurse Practitioners in the St. Louis metro area have a median pay of $62.21 per hour, about $129,390 a year. The middle half earn between $54.68 and $72.11 per hour (BLS, May 2024).

Is St. Louis a good place for nurse practitioners once cost of living is counted?

St. Louis ranks 139th of 336 metro areas for nurse practitioner pay after adjusting for local prices, and 126th of 372 before adjusting. Overall prices run 5% below the U.S. average.

Where do nurse practitioners work in St. Louis?

CMS lists 11 hospitals in St. Louis, led by Missouri Baptist Medical Center. Ask for the free report to see current openings and pay.

Do I need a Missouri license to work in St. Louis as a nurse practitioner?

Missouri is in the Nurse Licensure Compact, so an RN or LPN/LVN with a multistate license from another compact state can work here without a new license. Nurses whose home state is not in the compact apply for a Missouri license by endorsement. Confirm with the board before you accept a role.

Is St. Louis in a shortage area?

HRSA lists 5 active primary care shortage designations that include St. Louis city. Shortage areas often have more openings, and some loan repayment programs cover clinicians who work at eligible sites.

What is the per diem for a travel assignment in St. Louis?

The federal per diem benchmark in St. Louis is $150 a night for lodging and $86 a day for meals and incidentals, about $1,652 a week (GSA, fiscal year 2026). Your actual stipend depends on the assignment and your tax home.

Does Valorem Health place nurse practitioners in St. Louis?

Yes. We place healthcare staff in St. Louis and across Missouri. Tell us your profession and we email the roles open near St. Louis.

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What do employers near St. Louis pay nurse practitioners? Get the report.

Tell us your role and city. Within 24 hours you get an email with three things, by employer name. It costs you nothing, because employers pay us.

  1. 1
    Pay for your role at other hospitals

    The hourly pay at named employers near you, so you see who pays most.

  2. 2
    What they are offering now

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The Joint Commission Gold Seal of Approval: Health Care Staffing Services Certification, since 2022American Staffing Association memberNATHO member: National Association of Travel Healthcare OrganizationsNALTO member: National Association of Locum Tenens Organizations

Pay report · NP near St. Louis, MO
Valorem Health Shift ReportFrom your recruiting team · [email protected]

Your NP pay reportTop-paying hospitals shown · your Missouri list by name comes with the full report

1Pay for your role at other hospitals

  • MarinHealthGreenbrae, CA · 4 postings$96.91/ hr$86–$108
  • Sharp HealthCareSan Diego, CA · 6 postings$92.12/ hr$80–$104
  • Sharp HealthcareSan Diego, CA · 3 postings$92.12/ hr$80–$104
  • MemorialCareLong Beach, CA · 4 postings$89.59/ hr$70–$109

Median posted pay per hour, with the range each employer published. Request your Missouri list

2What they are offering now

Low$52Median$67.39High$89

424 NP postings with published pay in the US, 363 of them posted in the last 30 days. Month-by-month history by employer comes with your full report.

3Open now: 1 NP roles

  1. Advanced Practice NursePermanent
    $127k–$186k/ year
    Veterans Health Administration · Kansas City, MO · posted 9 days ago

Each one has pay, shift and start date.

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